| Pair Name | Morin, MST312 | ||
| Phytochemical Name | Morin (PubChem CID: 5281670 ) | ||
| Anticancer drug Name | MST312 (PubChem CID: 10385095 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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| Pair Name | Morin, MST312 | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Up-regulation | Phosphorylation | BAD | hsa572 | |
| Up-regulation | Phosphorylation | TP53 | hsa7157 | |
| Down-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Phosphorylation | NFKBIA | hsa4792 | |
| In Vitro Model | HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 | |
| Result | Our study suggests that novel targeted-therapy can be implemented by using flavonoid morin and telomerase inhibitor MST‑312 for improved cancer prognosis. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination treatment with flavonoid morin and telomerase inhibitor MST‑312 reduces cancer stem cell traits by targeting STAT3 and telomerase. Int J Oncol. 2016 Aug;49(2):487-98. doi: 10.3892/ijo.2016.3546. | Click |
